Collagenase clostridium histolyticum

Trade Names: Xiaflex Synonyms: Collagenase; CCH Drug Class: Enzyme Preparations:  Lyophilized powder containing 0.9 mg of collagenase in a single use vial Dose: For Dupuytren's contracture: 0.58 mg injected into a Dupuytren's contracture cord affecting an MCP or PIP joint. Perform dilution, injection and follow up (including a finger extension procedure if required, and splinting) according to the manufacturer's instructions. Only one cord injected at a time. Re-injection may be required. Indications: Read more [...]

Surgery – Indications

Orthopedic surgical procedures can dramatically improve the quality of life for patients with various types of arthritis.  In the past century, advances in surgical interventions have been among the most impactful innovation in the care of patients with musculoskeletal conditions. Types of Surgery: Commonly employed orthopedic procedures include: synovectomy or tenosynovectomy (i.e., removing synovial tissue from joints or tendons), ligament or tendon reconstruction (e.g., repair of Read more [...]


Trade Names: Remodulin (injection); Tyvaso (inhalation); Orenitram (oral) Synonyms: Prostacyclin, PGI2 Drug Class: Prostaglandin Preparations: Injection: 1-, 2.5-, 5-, 10 mg/ml Inhalation: 0.6 mg/ml with Tyvaso inhalation system Oral: 0.125-, 0.25-, 1-, 2.5 mg tablets Dose: Injection (subcutaneous or IV infusion): 1.25 ng/kg/minute initially and titrated slowly in small increments at approximately weekly intervals. Administered by a pump as a continuous subcutaneous injection or intravenous Read more [...]


Trade Names: Stelara Drug Class:  IL-12 and IL-23 inhibitor Preparations: Subcutaneous injection: 45 mg/0.5 mL  and 90 mg/mL (1 mL), both available as vials and prefilled syringes Dose: Adults with psoriatic arthritis: 45 mg by subcutaneous injection at weeks 0 and 4 and then every 12 weeks thereafter;  for adults with plaque psoriasis who weigh less than 100 kg - same dose as for psoriatic arthritis; for those weighing more than 100 kg - 90 mg at weeks 0 and 4 and then every 12 weeks Read more [...]


Trade Names: Levitra, Staxyn Drug Class: Phosphodiesterase 5 (PDE5) inhibitor Preparations: 2.5-, 5-, 10-, 20 mg tablets Dose: For erectile dysfunction 10 mg (range 5-20  mg) approximately 1 hour before sexual activity Indications: Erectile dysfunction; PDE5 inhibitors also tried in Raynaud's and for digital ulcers associated with scleroderma Mechanism of Action: Inhibits PDE5 and thus increases cyclic GMP concentrations causing vasodilation Contraindications: Hypersensitivity, Read more [...]


Trade Names: Cialis, Adcirca Drug Class: Phosphodiesterase 5 (PDE5) inhibitor Preparations: 2.5-, 5-, 10-, 20 mg tablets Dose: For pulmonary hypertension 40 mg once daily;  for erectile dysfunction 2.5-5 mg once daily or 5-20 mg episodically (not more than once daily) before sexual activity Indications: Erectile dysfuntion, pulmonary hypertension, benign prostatic hypertrophy, PDE5 inhibitors also tried in Raynaud's and for digital ulcers associated with scleroderma Mechanism Read more [...]


Trade Names: Viagra, Revatio Drug Class: Phosphodiesterase 5 (PDE5) inhibitor Preparations: Revatio 20 mg, Viagra 25-, 50-, 100 mg tablets Dose: For pulmonary hypertension 20 mg three times daily; for erectile dysfunction 50 mg 1 hour before sex Indications: Erectile dysfuntion (Viagra), pulmonary arterial hypertension (Revatio), sildenafil also tried in Raynaud's and for digital ulcers associated with scleroderma Mechanism of Action: Inhibits PDE5 and thus increases cyclic GMP Read more [...]


Trade Names: Lyrica Drug Class: Analgesic/anticonvulsant Preparations: 25-, 50-, 75-, 100-, 150-, 200-, 225-, 300 mg capsules Dose: Fibromyalgia: 75 mg twice a day may be increased stepwise to a maximum of 225 mg twice daily (i.e., maximum daily dose 450 mg). Reduce dose for renal impairment (see label). Indications: Fibromyalgia, diabetic neuropathy, neuropathic pain, post-herpetic neuralgia, partial-onset seizures Mechanism of Action: Binds to voltage-gated calcium channels in the Read more [...]


Trade Names: Actemra Drug Class: Biologic DMARD, IL-6 receptor antagonist Preparations: IV: 80 mg/4 mL, 200 mg/10 mL, 400 mg/20mL Subcutaneous injection: 162 mg/0.9 mL prefilled syringe Dose: Adults IV: initially 4 mg/kg every 4 weeks, dose  may be increased to 8 mg/kg depending on response, maximum dose is 800 mg. Subcutaneous injection:  less than 100 kg  - 162 mg every other week, may increase to every week depending on response; 100 kg or heavier - 162 mg every week. Adjust dose Read more [...]

Zoledronic acid

Trade Names: Reclast Drug Class: Bisphosphonate Preparations: 5 mg  in 100 mL i.v. preparation Dose/Administration Osteoporosis: for treatment 5 mg i.v. once a year; for prevention 5 mg i.v. every 2 years Paget’s disease: 5 mg i.v.,  consider retreatment for relapse Indications: Treatment and prevention of osteoporosis and glucocorticoid-induced osteoporosis; treatment of Paget’s disease, hypercalcemia of malignancy, multiple myeloma and metastases from solid tumors Mechanism Read more [...]

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