Orphenadrine CitrateRx

Last updated: October 20, 2014

Trade Names: Norflex

Drug Class: Muscle relaxant

Tablet: 100 mg

Dose: 100 mg twice daily

Indications: Treatment of muscle spasm

Mechanism of Action: Central atropine-like action is thought to induce skeletal muscle relaxation.

Contraindications: Hypersensitivity to orphenadrine, myasthenia gravis, bowel obstruction, glaucoma, prostatism

Precautions: Use caution with cardiac arrhythmias, may impair ability to operate machinery

Pregnancy Risk: C

Adverse Effects
Common: Drowsiness, blurred vision, dizziness
Less common: Tachycardia, rash, anticholinergic effects, nausea, constipation, flushing, confusion

Drug Interactions
Anticholinergics: Additive anticholinergic effects
CNS depressants: Additive CNS depression

Patient Instructions: May cause drowsiness. Avoid alcohol.

Clinical Pharmacology: Hepatic metabolism and renal excretion. Half-life is 14–16 hours.

Cost: $$$


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