Last updated: October 20, 2014
Trade Names: Norflex
Drug Class: Muscle relaxant
Tablet: 100 mg
Dose: 100 mg twice daily
Indications: Treatment of muscle spasm
Mechanism of Action: Central atropine-like action is thought to induce skeletal muscle relaxation.
Contraindications: Hypersensitivity to orphenadrine, myasthenia gravis, bowel obstruction, glaucoma, prostatism
Precautions: Use caution with cardiac arrhythmias, may impair ability to operate machinery
Pregnancy Risk: C
Common: Drowsiness, blurred vision, dizziness
Less common: Tachycardia, rash, anticholinergic effects, nausea, constipation, flushing, confusion
Anticholinergics: Additive anticholinergic effects
CNS depressants: Additive CNS depression
Patient Instructions: May cause drowsiness. Avoid alcohol.
Clinical Pharmacology: Hepatic metabolism and renal excretion. Half-life is 14–16 hours.