Last updated: October 17, 2014
Trade Names: Indocin
Drug Class: NSAID
Capsules: 25- and 50 mg
Capsule, extended release: 75 mg
Suspension oral: 25 mg/5 mL
Suppository: 50 mg
25–50 mg orally two to three times daily (1–2 mg/kg/day); maximum, 200 mg/day
Sustained-release capsule (75 mg) administered one or two times/day
Clinical Pharmacology: Well absorbed after oral administration; hepatic metabolism and renal excretion of metabolites; half-life 4–5 hours
Comments: Indomethacin may be more likely to cause CNS side effects (headaches, somnolence, cognitive dysfunction), particularly in the elderly.
See NSAIDs for Indications, Mechanism of Action, Contraindications, Precautions, Monitoring, Pregnancy Risk, Adverse Effects, Interactions, and Patient Instructions.