Last updated: October 17, 2014
Trade Names: Cataflam (immediate release), Voltaren (enteric coated) Voltaren XR (extended release), Arthrotec (diclofenac + misoprostol)
Drug Class: NSAID
Tablets: 25-, 50-, 75 mg; diclofenac/misoprostol: 50 mg/200 mcg or 75 mg/200 mcg
Sustained-release tablet (XR): 100 mg
Dose: 100–200 mg/day in two to four divided doses (100 mg once daily of sustained release)
Clinical Pharmacology: Well absorbed after oral administration; hepatic metabolism and renal excretion of metabolites; half-life 2–3 hours.
Comments: Local application of topical diclofenac (1% gel) may offer benefit to some patients with lower GI and CV risk.
See NSAIDs for Indications, Mechanism of Action, Contraindications, Precautions, Monitoring, Pregnancy Risk, Adverse Effects, Interactions, and Patient Instructions.
See Misoprostol for details regarding that component of Arthrotec (diclofenac + misoprostol).
Altman RD, Barthel HR. Topical therapies for osteoarthritis. Drugs 2011;71(10):1259-79. PMID: 21770475.