Last updated: October 6, 2014
Trade Names: Soma
Drug Class: Skeletal muscle relaxant
Tablet: 250-, 350 mg
Compound tablet: Carisoprodol 200 mg and aspirin 325 mg
Dose: Adults: 250 mg to 350 mg two to four times daily;
Recommended maximum duration of use is 2-3 weeks
Indications: Short term treatment of painful muscle spasm; useful in some patients with fibromyalgia
Mechanism of Action: Unknown; has a sedative effect and may modify pain perception
Contraindications: Hypersensitivity to carisoprodol or meprobamate; acute intermittent porphyria
Precautions: Use caution in renal or hepatic dysfunction. Avoid in elderly. Abuse potential. Operating machinery or driving under the effects of the drug are hazardous. Seizures.
Pregnancy Risk: C
Uncommon: Allergy, anaphylaxis, psychologic dependence and drug abuse, flushing, rash, nausea, fever, paradoxical stimulation, tremor, hematologic abnormalities, withdrawal symptoms after discontinuation of chronic therapy, seizures
CNS depressants: Increased CNS depression
Patient Instructions: Avoid alcohol. It may cause drowsiness.
Comments: Potential for abuse has resulted in it being removed from the market in several countries. Nighttime sedative effect is sometimes useful in improving sleep and pain control in fibromyalgia.
Clinical Pharmacology: Rapid oral absorption, hepatic metabolism via CYP2C19 to meprobamate (anxiolytic) that has a half-life of 10 hours, renal excretion. CYP2C19 poor metabolizers and patients receiving CYP2C19 inhibitors such as omeprazole may have higher concentrations of carisoprodol and lower concentrations of meprobamate.