Last updated: October 20, 2014
Trade Names: Nitro-Bid Ointment
Synonyms: Nitropaste, NTG, glyceryl trinitrate
Drug Class: Nitro vasodilator 1-, 30-, 60 g
Preparations: 2% ointment
Dose: For angina, 1/2 inch twice daily initially, increased to 1 inch twice daily if needed with a 12 hour nitrate free interval. For digital ulcers, smaller amounts are applied to the fingertips.
Indications: Angina, severe Raynaud’s syndrome with digital ulceration
Mechanism of Action: Nitric oxide donor. Nitric oxide acts through cyclic guanosine monophosphate to relax vascular smooth muscle.
Contraindications: Hypersensitivity to nitroglycerin, concommitant use of sildenafil (Viagra) or other phosphodiesterase-5 inhibitors
Pregnancy Risk: C
Common: Flushing, headache, dizziness, rash
Comments: Small amounts on tips of fingers tried for digital ulcers. Efficacy is uncertain.
Clinical Pharmacology: Systemic absorption occurs transdermally, and this preparation is used to treat angina. Duration of action is 10–12 hours.