Last updated: October 29, 2014

Trade Names: Relafen

Drug Class: NSAID

Preparations: 500- and 750-mg tablets

Dose: 1,000 mg/day in a single or divided doses. Dose may be increased to 1,500–2,000 mg/day in divided doses.

Clinical Pharmacology: Well absorbed after oral administration. Nabumetone is an inactive prodrug that is metabolized to the 6-methoxy-2-naphthyl acetic acid. Hepatic metabolism. Half-life is 20–30 hours (even longer in the elderly).

Cost: $$$

See NSAIDs for Indications, Mechanism of Action, Contraindications, Precautions, Monitoring, Pregnancy Risk, Adverse Effects, Interactions, and Patient Instructions.

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